Last update
5/30/2025

Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
25 mg
28%
Folate (from culture of S. cerevisiae)
400 mcg DFE
100%
Vitamin B12 (as Methylcobalamin from culture of S. cerevisiae)
500 mcg 
20833%
Iron (from Brown Rice Chelate)
22 mg 
122%
RAW Organic Fruit & Vegetable BlendOrganic Apple (fruit), Organic Beet (root), Organic Broccoli (stalk & flower), Organic Carrot (root), Organic Spinach (leaf), Organic Tomato (fruit), Organic Strawberry (fruit), Organic Tart Cherry (fruit), Organic Blackberry (fruit), Organic Green Bell Pepper (fruit), Organic Brussels Sprout (leaf), Organic Blueberry (fruit), Organic Ginger (root), Organic Garlic (bulb), Organic Green Onion (bulb), Organic Raspberry (fruit), Organic Parsley (leaf), Organic Cauliflower (flower & stem), Organic Red Cabbage (leaf), Organic Kale (leaf), Organic Cucumber (gourd), Organic Celery (stalk), Organic Asparagus Juice (flower & stem)
310 mg
+
RAW Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus plantarum, Lactobacillus bulgaricus] (500 Million CFU)
60 mg
+

Top Medical Research Studies

9
Endometrial cancer-induced angina case
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.

Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.

This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
Read More
We examined a unique case involving a 72-year-old Japanese man suffering from painful left bundle branch block (LBBB) syndrome coupled with iron-overload cardiomyopathy. This rare condition manifests as chest pain paired with transient LBBB, yet it occurs without the presence of ischemia—a condition that typically indicates heart problems.

Initially, we performed phlebotomy to reduce the excess iron in the heart muscle, aiming to address both the iron buildup and the conduction issues related to LBBB. Interestingly, we observed a remarkable improvement in the patient's chest pain once the LBBB became persistent and he experienced what is known as the walk-through phenomenon.

This case highlights an important therapeutic approach for managing painful LBBB syndrome that arises from cardiomyopathy. Given the absence of definitive treatment guidelines for this complex issue, a personalized treatment strategy is essential for each individual patient.
Read More
We explored the intriguing connection between iron treatment and chest pain in a patient diagnosed with persistent myocardial ischaemia due to iron-deficiency anaemia. This case involved a 36-year-old man who experienced significant heart issues, including a heart attack, and later suffered ongoing chest pain despite receiving oral iron supplements.

Through careful investigation, we discovered that his profound anaemia and subsequent chest issues were directly tied to undiagnosed coeliac disease. Once he received a proper diagnosis and switched to a strict gluten-free diet alongside continued iron supplementation, we observed a complete turnaround. Remarkably, just two months later, he reported no further chest pain, and his haemoglobin levels returned to normal.

This case highlights how critical it is to consider underlying conditions like coeliac disease when a patient presents with iron-deficiency anaemia. It also demonstrates how effective iron treatment can be when addressing chest pain rooted in such conditions.
Read More

Most Useful Reviews

7.5
Reduced chest pain
7 people found this helpful
Iron is crucial! After being diagnosed with anaemia, I was prescribed iron but discontinued due to stomach pain and nausea. I switched to this product, which contains iron, vitamins C and B12, folic acid, and probiotics. After 10 days, I noticed reduced shortness of breath and chest pain when climbing stairs. My energy has improved, and I felt happier. I experienced mild diarrhoea initially but now have no stomach issues. The iron content seems correct for me, and I'm excited to keep taking it daily.
Read More
9
No more chest pain
1 people found this helpful
Excellent iron supplement, gentle on my stomach. I finished my first bottle and, as someone with chronic anaemia, I’ve tried many iron supplements but often had to stop due to my sensitive gut. This iron caused no pain, and I’m finally free from the dizziness and light-headedness linked to low iron!
Read More
7.5
Improved chest pain
1 people found this helpful
I have significantly low iron and haemoglobin levels. Previous iron supplements caused me stomach pain, nausea, vomiting, and constipation. After finishing two boxes of this product, I consulted my doctor and ordered a third. After a month, I felt a positive change, especially regarding my chest pain.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.2
  • All Researches
We examined a unique case involving a 72-year-old Japanese man suffering from painful left bundle branch block (LBBB) syndrome coupled with iron-overload cardiomyopathy. This rare condition manifests as chest pain paired with transient LBBB, yet it occurs without the presence of ischemia—a condition that typically indicates heart problems.

Initially, we performed phlebotomy to reduce the excess iron in the heart muscle, aiming to address both the iron buildup and the conduction issues related to LBBB. Interestingly, we observed a remarkable improvement in the patient's chest pain once the LBBB became persistent and he experienced what is known as the walk-through phenomenon.

This case highlights an important therapeutic approach for managing painful LBBB syndrome that arises from cardiomyopathy. Given the absence of definitive treatment guidelines for this complex issue, a personalized treatment strategy is essential for each individual patient.
Read More
9.5
Pernicious anemia and thromboembolism
We explored a case involving a 46-year-old woman who experienced chest pain and hemoptysis, leading to the discovery of a pulmonary thromboembolism. Upon further evaluation, we found that her homocysteine levels were high and that she had low vitamin B12 and iron levels due to pernicious anemia.

Although she was diagnosed with multiple conditions, including pernicious anemia and iron-deficiency anemia, an interesting aspect of her treatment was the supplementation with vitamin B12 along with other necessary nutrients like pyridoxine, thiamine, folic acid, and iron. At the end of the therapy, not only did her vitamin B12 and folate levels return to normal, but also her homocysteine levels and red cell volume improved.

Ultimately, repeat imaging showed that the thrombus had completely resolved, suggesting a comprehensive approach to her treatment was effective. While vitamin B12 was part of her therapy, it was combined with several other treatments. Therefore, it is challenging to isolate its specific impact on her initial chest pain.

In summary, our findings point toward vitamin B12’s potential role in addressing underlying causes of hyperhomocysteinemia, but its direct effect on chest pain remains less clear-cut given the multifaceted treatment she received.
Read More
9.5
Vitamin B12 not isolated in study
We examined a group of 42 women suffering from chest pain but having normal coronary arteries, known as cardiac syndrome X. Our aim was to understand the link between a specific gene mutation (C677T) and abnormal homocysteine metabolism, a condition that may influence endothelial cell dysfunction, which has been tied to chest pain.

In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.

Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
Read More
9
Endometrial cancer-induced angina case
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.

Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.

This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
Read More
We explored the intriguing connection between iron treatment and chest pain in a patient diagnosed with persistent myocardial ischaemia due to iron-deficiency anaemia. This case involved a 36-year-old man who experienced significant heart issues, including a heart attack, and later suffered ongoing chest pain despite receiving oral iron supplements.

Through careful investigation, we discovered that his profound anaemia and subsequent chest issues were directly tied to undiagnosed coeliac disease. Once he received a proper diagnosis and switched to a strict gluten-free diet alongside continued iron supplementation, we observed a complete turnaround. Remarkably, just two months later, he reported no further chest pain, and his haemoglobin levels returned to normal.

This case highlights how critical it is to consider underlying conditions like coeliac disease when a patient presents with iron-deficiency anaemia. It also demonstrates how effective iron treatment can be when addressing chest pain rooted in such conditions.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Reduced chest pain
7 people found this helpful
Iron is crucial! After being diagnosed with anaemia, I was prescribed iron but discontinued due to stomach pain and nausea. I switched to this product, which contains iron, vitamins C and B12, folic acid, and probiotics. After 10 days, I noticed reduced shortness of breath and chest pain when climbing stairs. My energy has improved, and I felt happier. I experienced mild diarrhoea initially but now have no stomach issues. The iron content seems correct for me, and I'm excited to keep taking it daily.
Read More
9
No more chest pain
1 people found this helpful
Excellent iron supplement, gentle on my stomach. I finished my first bottle and, as someone with chronic anaemia, I’ve tried many iron supplements but often had to stop due to my sensitive gut. This iron caused no pain, and I’m finally free from the dizziness and light-headedness linked to low iron!
Read More
7.5
Improved chest pain
1 people found this helpful
I have significantly low iron and haemoglobin levels. Previous iron supplements caused me stomach pain, nausea, vomiting, and constipation. After finishing two boxes of this product, I consulted my doctor and ordered a third. After a month, I felt a positive change, especially regarding my chest pain.
Read More

Frequently Asked Questions

7.5
Reduced chest pain
7 people found this helpful
Iron is crucial! After being diagnosed with anaemia, I was prescribed iron but discontinued due to stomach pain and nausea. I switched to this product, which contains iron, vitamins C and B12, folic acid, and probiotics. After 10 days, I noticed reduced shortness of breath and chest pain when climbing stairs. My energy has improved, and I felt happier. I experienced mild diarrhoea initially but now have no stomach issues. The iron content seems correct for me, and I'm excited to keep taking it daily.
7.5
Improved chest pain
1 people found this helpful
I have significantly low iron and haemoglobin levels. Previous iron supplements caused me stomach pain, nausea, vomiting, and constipation. After finishing two boxes of this product, I consulted my doctor and ordered a third. After a month, I felt a positive change, especially regarding my chest pain.
9
No more chest pain
1 people found this helpful
Excellent iron supplement, gentle on my stomach. I finished my first bottle and, as someone with chronic anaemia, I’ve tried many iron supplements but often had to stop due to my sensitive gut. This iron caused no pain, and I’m finally free from the dizziness and light-headedness linked to low iron!
9
Endometrial cancer-induced angina case
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.

Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.

This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
We explored the intriguing connection between iron treatment and chest pain in a patient diagnosed with persistent myocardial ischaemia due to iron-deficiency anaemia. This case involved a 36-year-old man who experienced significant heart issues, including a heart attack, and later suffered ongoing chest pain despite receiving oral iron supplements.

Through careful investigation, we discovered that his profound anaemia and subsequent chest issues were directly tied to undiagnosed coeliac disease. Once he received a proper diagnosis and switched to a strict gluten-free diet alongside continued iron supplementation, we observed a complete turnaround. Remarkably, just two months later, he reported no further chest pain, and his haemoglobin levels returned to normal.

This case highlights how critical it is to consider underlying conditions like coeliac disease when a patient presents with iron-deficiency anaemia. It also demonstrates how effective iron treatment can be when addressing chest pain rooted in such conditions.
8
Folic acid improves angina symptoms
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.

Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.

Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
9.5
Vitamin B12 not isolated in study
We examined a group of 42 women suffering from chest pain but having normal coronary arteries, known as cardiac syndrome X. Our aim was to understand the link between a specific gene mutation (C677T) and abnormal homocysteine metabolism, a condition that may influence endothelial cell dysfunction, which has been tied to chest pain.

In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.

Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.

References

  1. Crawford G, Bahabri A, P'ng S. An atypical presentation of endometrial cancer as angina secondary to critically low hemoglobin and iron deficiency associated pancytopenia: A case report. Case Rep Womens Health. 2023;38:e00509. 10.1016/j.crwh.2023.e00509
  2. Oka S, Ito S, Kai T, Hoshino K, Watanabe K, et al. Painful Left Bundle Branch Block Syndrome Complicated by Iron-Overload Cardiomyopathy. Intern Med. 2021. 10.2169/internalmedicine.7052-21
  3. Gąsecka A, Kruk K, Przybyłkowski A, Mazurek T, Kochman J. Persistent Myocardial Ischaemia due to Anaemia in a Patient with Coeliac Disease - A Case Report. Heart Int. 2020;14:49. 10.17925/HI.2020.14.1.49
  4. He Z, Li N, Zhang W, Meng X, Wang J, et al. Efficacy and safety of Shexiang Baoxin Pill in patients with angina and non-obstructive coronary arteries: A multicenter, randomized, double-blind, placebo-controlled, phase Ⅳ clinical trial. Phytomedicine. 2025;139:156556. 10.1016/j.phymed.2025.156556
  5. Hoţoleanu C, Chouky E. Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages. Rom J Intern Med. 2012;50:313.
  6. Guo H, Chi J, Xing Y, Wang P. Influence of folic acid on plasma homocysteine levels & arterial endothelial function in patients with unstable angina. Indian J Med Res. 2009;129:279.
  7. Morrissey D, Sun Y, Koilpillai S, Kropf J, Carlan SJ. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Case Rep Med. 2022;2022:7306070. 10.1155/2022/7306070
  8. Liu F, Zhu L, Chen P, Shi Z, Liu S. [Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013;38:971. 10.3969/j.issn.1672-7347.2013.09.018
  9. Løland KH, Bleie Ø, Strand E, Ueland PM, Nordrehaug JE, et al. Effect of folic acid supplementation on levels of circulating Monocyte Chemoattractant Protein-1 and the presence of intravascular ultrasound derived virtual histology thin-cap fibroatheromas in patients with stable angina pectoris. PLoS One. 2013;8:e70101. 10.1371/journal.pone.0070101
  10. Küpeli E, Cengiz C, Cila A, Karnak D. Hyperhomocysteinemia due to pernicious anemia leading to pulmonary thromboembolism in a heterozygous mutation carrier. Clin Appl Thromb Hemost. 2008;14:365. 10.1177/1076029607305101
  11. Alroy S, Preis M, Barzilai M, Cassel A, Lavie L, et al. Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation. Isr Med Assoc J. 2007;9:321.
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