An atypical presentation of endometrial cancer as angina secondary to critically low hemoglobin and iron deficiency associated pancytopenia: A case report.
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
Read More
9.5
Iron treatment and chest pain
Painful Left Bundle Branch Block Syndrome Complicated by Iron-Overload Cardiomyopathy.
We examined a unique case involving a 72-year-old Japanese man suffering from painful left bundle branch block (LBBB) syndrome coupled with iron-overload cardiomyopathy. This rare condition manifests as chest pain paired with transient LBBB, yet it occurs without the presence of ischemia—a condition that typically indicates heart problems.
Initially, we performed phlebotomy to reduce the excess iron in the heart muscle, aiming to address both the iron buildup and the conduction issues related to LBBB. Interestingly, we observed a remarkable improvement in the patient's chest pain once the LBBB became persistent and he experienced what is known as the walk-through phenomenon.
This case highlights an important therapeutic approach for managing painful LBBB syndrome that arises from cardiomyopathy. Given the absence of definitive treatment guidelines for this complex issue, a personalized treatment strategy is essential for each individual patient.
Read More
9
Iron treatment improves chest pain
Persistent Myocardial Ischaemia due to Anaemia in a Patient with Coeliac Disease - A Case Report.
We explored the intriguing connection between iron treatment and chest pain in a patient diagnosed with persistent myocardial ischaemia due to iron-deficiency anaemia. This case involved a 36-year-old man who experienced significant heart issues, including a heart attack, and later suffered ongoing chest pain despite receiving oral iron supplements.
Through careful investigation, we discovered that his profound anaemia and subsequent chest issues were directly tied to undiagnosed coeliac disease. Once he received a proper diagnosis and switched to a strict gluten-free diet alongside continued iron supplementation, we observed a complete turnaround. Remarkably, just two months later, he reported no further chest pain, and his haemoglobin levels returned to normal.
This case highlights how critical it is to consider underlying conditions like coeliac disease when a patient presents with iron-deficiency anaemia. It also demonstrates how effective iron treatment can be when addressing chest pain rooted in such conditions.
Read More
Most Useful Reviews
7.5
Reduced chest pain
7 people found this helpful
Iron is crucial! After being diagnosed with anaemia, I was prescribed iron but discontinued due to stomach pain and nausea. I switched to this product, which contains iron, vitamins C and B12, folic acid, and probiotics. After 10 days, I noticed reduced shortness of breath and chest pain when climbing stairs. My energy has improved, and I felt happier. I experienced mild diarrhoea initially but now have no stomach issues. The iron content seems correct for me, and I'm excited to keep taking it daily.
Read More
9
No more chest pain
1 people found this helpful
Excellent iron supplement, gentle on my stomach. I finished my first bottle and, as someone with chronic anaemia, I’ve tried many iron supplements but often had to stop due to my sensitive gut. This iron caused no pain, and I’m finally free from the dizziness and light-headedness linked to low iron!
Read More
7.5
Improved chest pain
1 people found this helpful
I have significantly low iron and haemoglobin levels. Previous iron supplements caused me stomach pain, nausea, vomiting, and constipation. After finishing two boxes of this product, I consulted my doctor and ordered a third. After a month, I felt a positive change, especially regarding my chest pain.
We examined a unique case involving a 72-year-old Japanese man suffering from painful left bundle branch block (LBBB) syndrome coupled with iron-overload cardiomyopathy. This rare condition manifests as chest pain paired with transient LBBB, yet it occurs without the presence of ischemia—a condition that typically indicates heart problems.
Initially, we performed phlebotomy to reduce the excess iron in the heart muscle, aiming to address both the iron buildup and the conduction issues related to LBBB. Interestingly, we observed a remarkable improvement in the patient's chest pain once the LBBB became persistent and he experienced what is known as the walk-through phenomenon.
This case highlights an important therapeutic approach for managing painful LBBB syndrome that arises from cardiomyopathy. Given the absence of definitive treatment guidelines for this complex issue, a personalized treatment strategy is essential for each individual patient.
Read More
9.5
Pernicious anemia and thromboembolism
Hyperhomocysteinemia due to pernicious anemia leading to pulmonary thromboembolism in a heterozygous mutation carrier.
We explored a case involving a 46-year-old woman who experienced chest pain and hemoptysis, leading to the discovery of a pulmonary thromboembolism. Upon further evaluation, we found that her homocysteine levels were high and that she had low vitamin B12 and iron levels due to pernicious anemia.
Although she was diagnosed with multiple conditions, including pernicious anemia and iron-deficiency anemia, an interesting aspect of her treatment was the supplementation with vitamin B12 along with other necessary nutrients like pyridoxine, thiamine, folic acid, and iron. At the end of the therapy, not only did her vitamin B12 and folate levels return to normal, but also her homocysteine levels and red cell volume improved.
Ultimately, repeat imaging showed that the thrombus had completely resolved, suggesting a comprehensive approach to her treatment was effective. While vitamin B12 was part of her therapy, it was combined with several other treatments. Therefore, it is challenging to isolate its specific impact on her initial chest pain.
In summary, our findings point toward vitamin B12’s potential role in addressing underlying causes of hyperhomocysteinemia, but its direct effect on chest pain remains less clear-cut given the multifaceted treatment she received.
Read More
9.5
Vitamin B12 not isolated in study
Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation.
We examined a group of 42 women suffering from chest pain but having normal coronary arteries, known as cardiac syndrome X. Our aim was to understand the link between a specific gene mutation (C677T) and abnormal homocysteine metabolism, a condition that may influence endothelial cell dysfunction, which has been tied to chest pain.
In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.
Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
Read More
9
Endometrial cancer-induced angina case
An atypical presentation of endometrial cancer as angina secondary to critically low hemoglobin and iron deficiency associated pancytopenia: A case report.
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
Read More
9
Iron treatment improves chest pain
Persistent Myocardial Ischaemia due to Anaemia in a Patient with Coeliac Disease - A Case Report.
We explored the intriguing connection between iron treatment and chest pain in a patient diagnosed with persistent myocardial ischaemia due to iron-deficiency anaemia. This case involved a 36-year-old man who experienced significant heart issues, including a heart attack, and later suffered ongoing chest pain despite receiving oral iron supplements.
Through careful investigation, we discovered that his profound anaemia and subsequent chest issues were directly tied to undiagnosed coeliac disease. Once he received a proper diagnosis and switched to a strict gluten-free diet alongside continued iron supplementation, we observed a complete turnaround. Remarkably, just two months later, he reported no further chest pain, and his haemoglobin levels returned to normal.
This case highlights how critical it is to consider underlying conditions like coeliac disease when a patient presents with iron-deficiency anaemia. It also demonstrates how effective iron treatment can be when addressing chest pain rooted in such conditions.
Iron is crucial! After being diagnosed with anaemia, I was prescribed iron but discontinued due to stomach pain and nausea. I switched to this product, which contains iron, vitamins C and B12, folic acid, and probiotics. After 10 days, I noticed reduced shortness of breath and chest pain when climbing stairs. My energy has improved, and I felt happier. I experienced mild diarrhoea initially but now have no stomach issues. The iron content seems correct for me, and I'm excited to keep taking it daily.
Read More
9
No more chest pain
1 people found this helpful
Excellent iron supplement, gentle on my stomach. I finished my first bottle and, as someone with chronic anaemia, I’ve tried many iron supplements but often had to stop due to my sensitive gut. This iron caused no pain, and I’m finally free from the dizziness and light-headedness linked to low iron!
Read More
7.5
Improved chest pain
1 people found this helpful
I have significantly low iron and haemoglobin levels. Previous iron supplements caused me stomach pain, nausea, vomiting, and constipation. After finishing two boxes of this product, I consulted my doctor and ordered a third. After a month, I felt a positive change, especially regarding my chest pain.
Read More
Frequently Asked Questions
Chest pain is a broad term that refers to discomfort or pain felt in the chest area, and it can arise from a variety of causes. It can range from a sharp, stabbing sensation to a dull ache or pressure. Some common causes of chest pain include heart-related issues, such as angina or heart attacks, as well as non-cardiac conditions like acid reflux, musculoskeletal problems, or anxiety. Since chest pain can represent a serious condition, especially if it is sudden and severe, it's crucial to pay attention to accompanying symptoms such as shortness of breath, sweating, or nausea, which may warrant immediate medical attention.
If you're experiencing chest pain, it's essential to consult a healthcare professional for an accurate diagnosis. They may perform tests such as an electrocardiogram (ECG), blood tests, or imaging studies to determine the underlying cause. Early identification of heart-related issues can be life-saving, while non-cardiac causes, though often less serious, still require appropriate assessment and treatment. Understanding the context and quality of the pain can help guide that conversation with your doctor, ensuring you receive the best care possible.
Iron is a chemical element with the symbol Fe, derived from the Latin word "ferrum." It is a metal that is known for its strength and versatility, making it one of the most widely used materials in construction, manufacturing, and various industrial applications. Iron is the fourth most abundant element in the universe by mass and is primarily obtained through the mining of iron ores, such as hematite and magnetite. Once mined, it undergoes processes like smelting and refining to produce usable forms like cast iron, wrought iron, and steel.
In addition to its industrial uses, iron is also crucial for human health, as it plays a significant role in the production of hemoglobin, the protein in red blood cells responsible for transporting oxygen throughout the body. A deficiency in iron can lead to anemia, characterized by fatigue and weakened immunity. Overall, iron is a fundamental element that supports modern infrastructure and is vital for maintaining good health.
Based on user reviews, the time it takes to see results from this supplement for chest pain varies, but many users have reported noticeable improvements within a short period. For instance, one user mentioned feeling better after just 10 days, with reduced chest pain and improved energy levels when engaging in physical activity, such as climbing stairs Read Review. Another reviewer indicated that after a month of consistent use, they noticed a positive change related to their chest pain alongside an increase in overall well-being Read Review.
Overall, while individual results may vary based on personal health circumstances and adherence to the supplement regimen, many users suggest that improvements can often be felt within weeks. It may be beneficial to consult with a healthcare provider to tailor the approach to your specific needs and to monitor progress effectively.
Based on available scientific research, there are various supplements that have shown potential benefits in addressing chest pain. For instance, iron treatment has been associated with alleviating chest pain caused by conditions like severe anemia and coeliac disease. In one case, a patient's chest pain resolved after receiving iron supplementation alongside blood transfusions, indicating that treating the underlying anemia can lead to significant symptom relief [1]. Similarly, another study highlighted that iron therapy helped address chest pain linked to myocardial ischaemia due to iron-deficiency anemia, emphasizing the importance of diagnosing and treating underlying conditions [3].
Additionally, folic acid supplementation has been explored in connection with chest pain. Research showed that patients with unstable angina experienced some benefits from folic acid treatment, which effectively lowered homocysteine levels and improved arterial function [6]. However, the role of vitamin B12 in treating chest pain remains less clear and often intertwines with complex treatment regimens, making it challenging to isolate its specific effects on chest pain [11]. Overall, while some supplements like iron and folic acid are supported by scientific studies in managing symptoms associated with chest pain, more research is needed to clarify the effects of others, such as vitamin B12, in this context.
Based on user reviews, many individuals have reported notable improvements in their symptoms after using this iron supplement. For instance, one user shared that after just 10 days of use, they experienced reduced shortness of breath and chest pain when engaging in physical activities like climbing stairs, coupled with increased energy levels and an overall boost in happiness Read Review. Another reviewer with chronic anemia noted a significant alleviation of dizziness and light-headedness, symptoms they attributed to low iron, thanks to the gentle formulation of the supplement Read Review.
In addition, a user with very low iron and hemoglobin levels reported a positive change in their chest pain after a month of consistent use, pointing to the effectiveness of the product in addressing their iron deficiency without the common side effects associated with other supplements Read Review. While these experiences suggest that improvements can be substantial, it is important to remember that individual results may vary, and consulting a healthcare provider is advisable for personalized guidance.
Based on user reviews, many individuals report positive outcomes when using iron supplements to address chest pain related to anaemia. One user noted that after switching to an iron supplement that also includes vitamins C and B12, they experienced reduced chest pain and shortness of breath when performing physical activities, such as climbing stairs, indicating that the dosage was effective for their needs Read Review. Similarly, another user highlighted significant improvement in their symptoms, including chest pain, after consistently using their iron supplement for a month, confirming that after two boxes, they were encouraged to seek further guidance from their doctor Read Review.
While experiences vary, a common thread among these reviews suggests that the right dose appears to hinge upon individual tolerance and the specific formulation of the iron product used. Users with sensitive stomachs emphasized the importance of finding gentle iron supplements that do not provoke gastrointestinal issues, as this was crucial in allowing them to continue their regimen without the adverse effects that led to discontinuation of other products Read Review. Overall, a tailored approach to dosing, considering individual health circumstances, seems essential in effectively managing symptoms like chest pain related to low iron.
7.5
Reduced chest pain
7 people found this helpful
Iron is crucial! After being diagnosed with anaemia, I was prescribed iron but discontinued due to stomach pain and nausea. I switched to this product, which contains iron, vitamins C and B12, folic acid, and probiotics. After 10 days, I noticed reduced shortness of breath and chest pain when climbing stairs. My energy has improved, and I felt happier. I experienced mild diarrhoea initially but now have no stomach issues. The iron content seems correct for me, and I'm excited to keep taking it daily.
7.5
Improved chest pain
1 people found this helpful
I have significantly low iron and haemoglobin levels. Previous iron supplements caused me stomach pain, nausea, vomiting, and constipation. After finishing two boxes of this product, I consulted my doctor and ordered a third. After a month, I felt a positive change, especially regarding my chest pain.
9
No more chest pain
1 people found this helpful
Excellent iron supplement, gentle on my stomach. I finished my first bottle and, as someone with chronic anaemia, I’ve tried many iron supplements but often had to stop due to my sensitive gut. This iron caused no pain, and I’m finally free from the dizziness and light-headedness linked to low iron!
9
Endometrial cancer-induced angina case
An atypical presentation of endometrial cancer as angina secondary to critically low hemoglobin and iron deficiency associated pancytopenia: A case report.
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
9
Iron treatment improves chest pain
Persistent Myocardial Ischaemia due to Anaemia in a Patient with Coeliac Disease - A Case Report.
We explored the intriguing connection between iron treatment and chest pain in a patient diagnosed with persistent myocardial ischaemia due to iron-deficiency anaemia. This case involved a 36-year-old man who experienced significant heart issues, including a heart attack, and later suffered ongoing chest pain despite receiving oral iron supplements.
Through careful investigation, we discovered that his profound anaemia and subsequent chest issues were directly tied to undiagnosed coeliac disease. Once he received a proper diagnosis and switched to a strict gluten-free diet alongside continued iron supplementation, we observed a complete turnaround. Remarkably, just two months later, he reported no further chest pain, and his haemoglobin levels returned to normal.
This case highlights how critical it is to consider underlying conditions like coeliac disease when a patient presents with iron-deficiency anaemia. It also demonstrates how effective iron treatment can be when addressing chest pain rooted in such conditions.
8
Folic acid improves angina symptoms
Influence of folic acid on plasma homocysteine levels & arterial endothelial function in patients with unstable angina.
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
9.5
Vitamin B12 not isolated in study
Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation.
We examined a group of 42 women suffering from chest pain but having normal coronary arteries, known as cardiac syndrome X. Our aim was to understand the link between a specific gene mutation (C677T) and abnormal homocysteine metabolism, a condition that may influence endothelial cell dysfunction, which has been tied to chest pain.
In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.
Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
References
Crawford G, Bahabri A, P'ng S. An atypical presentation of endometrial cancer as angina secondary to critically low hemoglobin and iron deficiency associated pancytopenia: A case report. Case Rep Womens Health. 2023;38:e00509. 10.1016/j.crwh.2023.e00509
Oka S, Ito S, Kai T, Hoshino K, Watanabe K, et al. Painful Left Bundle Branch Block Syndrome Complicated by Iron-Overload Cardiomyopathy. Intern Med. 2021. 10.2169/internalmedicine.7052-21
Gąsecka A, Kruk K, Przybyłkowski A, Mazurek T, Kochman J. Persistent Myocardial Ischaemia due to Anaemia in a Patient with Coeliac Disease - A Case Report. Heart Int. 2020;14:49. 10.17925/HI.2020.14.1.49
He Z, Li N, Zhang W, Meng X, Wang J, et al. Efficacy and safety of Shexiang Baoxin Pill in patients with angina and non-obstructive coronary arteries: A multicenter, randomized, double-blind, placebo-controlled, phase Ⅳ clinical trial. Phytomedicine. 2025;139:156556. 10.1016/j.phymed.2025.156556
Hoţoleanu C, Chouky E. Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages. Rom J Intern Med. 2012;50:313.
Guo H, Chi J, Xing Y, Wang P. Influence of folic acid on plasma homocysteine levels & arterial endothelial function in patients with unstable angina. Indian J Med Res. 2009;129:279.
Morrissey D, Sun Y, Koilpillai S, Kropf J, Carlan SJ. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Case Rep Med. 2022;2022:7306070. 10.1155/2022/7306070
Liu F, Zhu L, Chen P, Shi Z, Liu S. [Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013;38:971. 10.3969/j.issn.1672-7347.2013.09.018
Løland KH, Bleie Ø, Strand E, Ueland PM, Nordrehaug JE, et al. Effect of folic acid supplementation on levels of circulating Monocyte Chemoattractant Protein-1 and the presence of intravascular ultrasound derived virtual histology thin-cap fibroatheromas in patients with stable angina pectoris. PLoS One. 2013;8:e70101. 10.1371/journal.pone.0070101
Küpeli E, Cengiz C, Cila A, Karnak D. Hyperhomocysteinemia due to pernicious anemia leading to pulmonary thromboembolism in a heterozygous mutation carrier. Clin Appl Thromb Hemost. 2008;14:365. 10.1177/1076029607305101
Alroy S, Preis M, Barzilai M, Cassel A, Lavie L, et al. Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation. Isr Med Assoc J. 2007;9:321.